Isolated hepatic perfusion for patients with liver metastases
نویسندگان
چکیده
منابع مشابه
Isolated hepatic melphalan perfusion of colorectal liver metastases: outcome and prognostic factors in 154 patients.
BACKGROUND The aim of this study was to identify prognostic factors for local and systemic failure after isolated hepatic perfusion (IHP) with 200 mg melphalan in patients with colorectal liver metastases. PATIENTS AND METHODS Hundred and fifty-four patients were selected for IHP and underwent laparotomy. Patients were monitored for response, toxicity and survival. Univariate and multivariate...
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PURPOSE Liver metastases are the sole or life-limiting component of disease in the majority of patients with ocular melanoma who recur. Because median survival after diagnosis of liver metastases is short and no satisfactory treatment options exist, we have conducted clinical trials evaluating isolated hepatic perfusion (IHP) for patients afflicted with this condition. EXPERIMENTAL DESIGN Twe...
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In a recent issue of Annals of Oncology, Zelek et al. reported on a combination treatment of systemic [5-fluorouracil (5-FU), leucovorin (LV) and irinotecan] and hepatic arterial (pirarubicin) chemotherapy in the first-line treatment of non-resectable, metastatic colorectal cancer limited to the liver [1]. In their article, the authors report a response rate of 48% and a median survival of 20.5...
متن کاملChemosaturation With Percutaneous Hepatic Perfusion in Unresectable Hepatic Metastases.
BACKGROUND In patients with hepatic metastases from solid-organ malignancies, surgical resection may be a potentially curative option, but it is not possible in most cases. Chemosaturation with percutaneous hepatic perfusion was developed for the management of unresectable metastases to the liver. METHODS Relevant medical literature was summarized with regard to the outcomes and limitations o...
متن کاملTNF-based isolated hepatic perfusion.
Unresectable primary and metastatic cancers confined to the liver often determine the prognosis for patients with primary hepatic cancers, colorectal cancer, ocular melanoma, and neuroendocrine tumors. Although many locoregional therapies have emerged as options for patients with unresectable liver malignancies, these treatments frequently have limited clinical benefit. Isolated hepatic perfusi...
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ژورنال
عنوان ژورنال: Therapeutic Advances in Medical Oncology
سال: 2014
ISSN: 1758-8359,1758-8359
DOI: 10.1177/1758834014529175